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session 81207 - Total of 3 hits - Display hits per page:

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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
FLUDARABINE (is an active metabolite) (has an active metabolite)	FLUDARABINE	ATC L01BB05 ANTINEOPLASTIC ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS PHOSPHORYLATED BY DEOXYCYTIDINE KINASE TO THE ACTIVE TRIPHOSPHATE	-	Tmax 1.5 HOUR F 57 PERCENT VD 143 LITER (65 KILOGRAM) PPB 24 PERCENT Cl 12.4 LITER / HOUR (65 KILOGRAM) HT 20 HOUR	DEOXYCYTIDINE KINASE	DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
FLUDARABINE PHOSPHATE (has an active metabolite)	FLUDARABINE PHOSPHATE	ATC L01BB05 ANTINEOPLASTIC ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS RAPIDLY DEPHOSPHORYLATED INTO FLUDARABINE AND THEN PHOSPHORYLATED BY DEOXYCYTIDINE KINASE TO THE ACTIVE TRIPHOSPHATE	INJECTION ORAL		DNA POLYMERASE ALPHA, GAMMA AND DELTA RIBONUCLEOTIDE DIPHOSPHATE REDUCTASE DNA PRIMASE DNA LIGASE I	DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
3	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M FLUDARABINE (is an active metabolite)	FLUDARABINE	ATC L01BB05 ANTINEOPLASTIC ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS FLUDARABINE PHOSPHATE IS RAPIDLY DEPHOSPHORYLATED AND THEN PHOSPHORYLATED BY DEOXYCYTIDINE KINASE TO THE ACTIVE TRIPHOSPHATE	-		DNA POLYMERASE ALPHA, GAMMA AND DELTA RIBONUCLEOTIDE DIPHOSPHATE REDUCTASE DNA PRIMASE DNA LIGASE I PDB 6DWK (SAMHD1 BOUND TO FLUDARABINE-TP IN THE CATALYTIC POCKET) LIGAND CODE = HFD (link to the list of PDB complexes) Download experimental 3D coordinates of HFD with added hydrogens	DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank