PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
ANTINEOPLASTIC ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS PHOSPHORYLATED BY DEOXYCYTIDINE KINASE TO THE ACTIVE TRIPHOSPHATE
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Tmax 1.5 HOUR
F 57 PERCENT
VD 143 LITER (65 KILOGRAM)
PPB 24 PERCENT
Cl 12.4 LITER / HOUR (65 KILOGRAM)
HT 20 HOUR
DEOXYCYTIDINE KINASE
DNA POLYMERASE (ALPHA/DELTA/EPSILON) INHIBITOR CHEMBL2363042 DNA POLYMERASE (ALPHA/DELTA/EPSILON) P09884 DNA POLYMERASE ALPHA CATALYTIC SUBUNIT HOMO SAPIENS ENZYME TRANSFERASE
PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
ANTINEOPLASTIC ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS RAPIDLY DEPHOSPHORYLATED INTO FLUDARABINE AND THEN PHOSPHORYLATED BY DEOXYCYTIDINE KINASE TO THE ACTIVE TRIPHOSPHATE
INJECTION ORAL
DNA POLYMERASE ALPHA, GAMMA AND DELTA RIBONUCLEOTIDE DIPHOSPHATE REDUCTASE DNA PRIMASE DNA LIGASE I
DNA POLYMERASE (ALPHA/DELTA/EPSILON) INHIBITOR CHEMBL2363042 DNA POLYMERASE (ALPHA/DELTA/EPSILON) P09884 DNA POLYMERASE ALPHA CATALYTIC SUBUNIT HOMO SAPIENS ENZYME TRANSFERASE