PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
ANTINEOPLASTIC ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS PHOSPHORYLATED BY DEOXYCYTIDINE KINASE TO THE ACTIVE TRIPHOSPHATE
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Tmax 1.5 HOUR
F 57 PERCENT
VD 143 LITER (65 KILOGRAM)
PPB 24 PERCENT
Cl 12.4 LITER / HOUR (65 KILOGRAM)
HT 20 HOUR
DEOXYCYTIDINE KINASE
DNA POLYMERASE (ALPHA/DELTA/EPSILON) INHIBITOR CHEMBL2363042 DNA POLYMERASE (ALPHA/DELTA/EPSILON) P09884 DNA POLYMERASE ALPHA CATALYTIC SUBUNIT HOMO SAPIENS ENZYME TRANSFERASE
PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
ANTINEOPLASTIC ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS FLUDARABINE PHOSPHATE IS RAPIDLY DEPHOSPHORYLATED AND THEN PHOSPHORYLATED BY DEOXYCYTIDINE KINASE TO THE ACTIVE TRIPHOSPHATE
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DNA POLYMERASE ALPHA, GAMMA AND DELTA RIBONUCLEOTIDE DIPHOSPHATE REDUCTASE DNA PRIMASE DNA LIGASE I
PDB6DWK (SAMHD1 BOUND TO FLUDARABINE-TP IN THE CATALYTIC POCKET)
DNA POLYMERASE (ALPHA/DELTA/EPSILON) INHIBITOR CHEMBL2363042 DNA POLYMERASE (ALPHA/DELTA/EPSILON) P09884 DNA POLYMERASE ALPHA CATALYTIC SUBUNIT HOMO SAPIENS ENZYME TRANSFERASE