Cheminformatic Tools and Databases for Pharmacology

session 64167 - Total of 4 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DIAZEPAM (has an active metabolite)

DIAZEPAM


ATC N05BA01

NERVOUS SYSTEM
ANXIOLYTIC
ANESTHETICS
ANTICONVULSANTS
ANTIEMETICS
GABA AGONIST
HYPNOTICS AND SEDATIVES
MUSCLE RELAXANTS, CENTRAL
BENZODIAZEPINE

ORAL INJECTION RECTAL NASAL

Tmax 1.25 HOUR

F 90 PERCENT

VD 58.5 LITER (65 KILOGRAM)

PPB 98 PERCENT

Cl 1.5 LITER / HOUR

HT 46 HOUR

SOLUBILITY INSOLUBLE IN WATER

GAMMA-AMINOBUTYRIC-ACID RECEPTOR

PDB 2BXF (HUMAN SERUM ALBUMIN COMPLEXED WITH DIAZEPAM)

LIGAND CODE = DZP (link to the list of PDB complexes)

Download experimental 3D coordinates of DZP with added hydrogens

GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAAANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M DIAZEPAM (is an active metabolite) (has an active metabolite)

DIAZEPAM


ATC N05BA01

NERVOUS SYSTEM
ANXIOLYTIC
BENZODIAZEPINES
MUSCLE RELAXANTS
SEDATIVE

-

VD 29.2 LITER (65 KILOGRAM)

PPB 97 PERCENT

Cl 0.46 LITER / HOUR (65 KILOGRAM)

HT 46 HOUR

GAMMA-AMINOBUTYRIC-ACID RECEPTOR

GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAAANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

3 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TEMAZEPAM (is an active metabolite) (has an active metabolite)

TEMAZEPAM


ATC N05CD07

NERVOUS SYSTEM
HYPNOTICS AND SEDATIVES
BENZODIAZEPINES
GABA MODULATORS
ALLOSTERIC POSITIVE

ORAL

Cmax 2.7 MICROMOLAR

F 92 PERCENT

PPB 96 PERCENT

HT 8.8 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

GABA RECEPTOR

GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAAANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

4 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TEMAZEPAM (is an active metabolite)

TEMAZEPAM


ATC N05CD07

NERVOUS SYSTEM
HYPNOTICS AND SEDATIVES
BENZODIAZEPINES
GABA MODULATORS
ALLOSTERIC POSITIVE

ORAL

Cmax 2.7 MICROMOLAR

Tmax 1.5 HOUR

F 92 PERCENT

PPB 96 PERCENT

HT 8.8 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

GABA RECEPTOR

GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAAANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |