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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DIAZEPAM (has an active metabolite)
| DIAZEPAM | NERVOUS SYSTEM | ORAL INJECTION RECTAL NASAL BUCCAL | Tmax 1.25 HOUR F 90 PERCENT VD 58.5 LITER (65 KILOGRAM) PPB 98 PERCENT Cl 1.5 LITER / HOUR HT 46 HOUR SOLUBILITY INSOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR PDB 2BXF (HUMAN SERUM ALBUMIN COMPLEXED WITH DIAZEPAM) LIGAND CODE = DZP (link to the list of PDB complexes) Download experimental 3D coordinates of DZP with added hydrogens | GABA A receptor alpha-5,beta-2,gamma-3 UNIPROT P31644 GABRA5 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TEMAZEPAM (is an active metabolite)
| TEMAZEPAM | NERVOUS SYSTEM | ORAL | Cmax 2.7 MICROMOLAR Tmax 1.5 HOUR F 92 PERCENT PPB 96 PERCENT HT 8.8 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | GABA RECEPTOR | GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 more at DrugCentral | EMA | |||
