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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CLORAZEPATE (has an active metabolite)
| CLORAZEPATE | NERVOUS SYSTEM | ORAL | VD 13 LITER (65 KILOGRAM) Cl 4.29 LITER / HOUR (65 KILOGRAM) HT 2.4 HOUR SOLUBILITY SOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABA) | GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAA | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CLORAZEPATE (has an active metabolite)
| CLORAZEPATE | NERVOUS SYSTEM | ORAL | VD 13 LITER (65 KILOGRAM) Cl 4.29 LITER / HOUR (65 KILOGRAM) HT 2.4 HOUR SOLUBILITY SOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABA) | GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAA | EMA | |||
| 3 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DIAZEPAM (has an active metabolite)
| DIAZEPAM | NERVOUS SYSTEM | ORAL INJECTION RECTAL NASAL BUCCAL | Tmax 1.25 HOUR F 90 PERCENT VD 58.5 LITER (65 KILOGRAM) PPB 98 PERCENT Cl 1.5 LITER / HOUR HT 46 HOUR SOLUBILITY INSOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR PDB 2BXF (HUMAN SERUM ALBUMIN COMPLEXED WITH DIAZEPAM) LIGAND CODE = DZP (link to the list of PDB complexes) Download experimental 3D coordinates of DZP with added hydrogens | GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAA | EMA | |||
| 4 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| HALAZEPAM DISCONTINUED (has an active metabolite)
| HALAZEPAM | NERVOUS SYSTEM | ORAL | VD 732 LITER (EQN) Cl 24 LITER / HOUR (PMID1980307) HT 21.15 HOUR | GAMMA-AMINOBUTYRIC-ACID RECEPTOR | GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAA | EMA | |||
| 5 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M DIAZEPAM (is an active metabolite) (has an active metabolite)
| DIAZEPAM | NERVOUS SYSTEM | - | VD 29.2 LITER (65 KILOGRAM) PPB 97 PERCENT Cl 0.46 LITER / HOUR (65 KILOGRAM) HT 46 HOUR | GAMMA-AMINOBUTYRIC-ACID RECEPTOR | GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAA | EMA | |||
| 6 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PRAZEPAM DISCONTINUED (has an active metabolite)
| PRAZEPAM | NERVOUS SYSTEM | ORAL | GAMMA-AMINOBUTYRIC-ACID RECEPTOR | GABA-A RECEPTOR ANION CHANNEL POSITIVE ALLOSTERIC MODULATOR CHEMBL2093872 GABA-A RECEPTOR ANION CHANNEL P14867 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HOMO SAPIENS ION CHANNEL LGIC GABAA | EMA | ||||
