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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLUDARABINE (is an active metabolite) (has an active metabolite)
| FLUDARABINE | ANTINEOPLASTIC | - | Tmax 1.5 HOUR F 57 PERCENT VD 143 LITER (65 KILOGRAM) PPB 24 PERCENT Cl 12.4 LITER / HOUR (65 KILOGRAM) HT 20 HOUR | DEOXYCYTIDINE KINASE | DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M FLUDARABINE (is an active metabolite)
| FLUDARABINE | ANTINEOPLASTIC | - | DNA POLYMERASE ALPHA, GAMMA AND DELTA RIBONUCLEOTIDE DIPHOSPHATE REDUCTASE DNA PRIMASE DNA LIGASE I PDB 6DWK (SAMHD1 BOUND TO FLUDARABINE-TP IN THE CATALYTIC POCKET) LIGAND CODE = HFD (link to the list of PDB complexes) Download experimental 3D coordinates of HFD with added hydrogens | DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 more at DrugCentral | EMA | ||||
