Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine

Formula:
C17H26ClN

Calculated chemical properties:

MW 279.84
NB_atoms 19
XLogP 4.74
PSA 2.419
NB_HD 0
NB_HA 1
fsp3 0.65
Lipinski(0=no;1=yes) 1

FDA
NDA 020632 (label) INN (SIBUTRAMINE HYDROCHLORIDE) MERIDIA (ABBOTT) APPROVAL= AP YEAR= 1997 DISCONTINUED

Other links:

e-Drug3D

1657

M SIBUTRAMINE

INN
SIBUTRAMINE

cas 168835-59-4

CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

ROUTE (list)

ATC code

A08AA10

PK parameters

Tmax 3.6 HOUR
Cmax 15 NANOMOLAR
PPB 94 PERCENT
t1/2 14 HOUR

Target

TARGET MONOAMINE REUPTAKE

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

Cyclobutanemethanamine, 1-(4-chlorophenyl)-N-methyl-alpha-(2-methylpropyl)-

Formula:
C16H24ClN

Calculated chemical properties:

MW 265.81
NB_atoms 18
XLogP 4.40
PSA 8.206
NB_HD 1
NB_HA 1
fsp3 0.62
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

e-Drug3D

1658

M SIBUTRAMINE

INN
SIBUTRAMINE

cas 168835-59-4

CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

ROUTE (list)

ATC code

A08AA10

PK parameters

Tmax 3.6 HOUR
Cmax 15 NANOMOLAR
PPB 94 PERCENT
t1/2 14 HOUR

Target

TARGET MONOAMINE REUPTAKE

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

Cyclobutanemethanamine, 1-(4-chlorophenyl)-N-methyl-alpha-(2-methylpropyl)-

Formula:
C16H24ClN

Calculated chemical properties:

MW 265.81
NB_atoms 18
XLogP 4.40
PSA 12.593
NB_HD 1
NB_HA 1
fsp3 0.62
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

e-Drug3D

1659

M SIBUTRAMINE

INN
SIBUTRAMINE

cas 84467-54-9

CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

ROUTE (list)

ATC code

A08AA10

PK parameters

Tmax 3.5 HOUR
Cmax 25.4 NANOMOLAR
PPB 94 PERCENT
t1/2 16 HOUR

Target

TARGET MONOAMINE REUPTAKE

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

Cyclobutanemethanamine, 1-(4-chlorophenyl)-alpha-(2-methylpropyl)-

Formula:
C15H22ClN

Calculated chemical properties:

MW 251.79
NB_atoms 17
XLogP 4.14
PSA 19.082
NB_HD 2
NB_HA 1
fsp3 0.60
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

e-Drug3D

1660

M SIBUTRAMINE

INN
SIBUTRAMINE

cas 84467-54-9

CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

ROUTE (list)

ATC code

A08AA10

PK parameters

Tmax 3.5 HOUR
Cmax 25.4 NANOMOLAR
PPB 94 PERCENT
t1/2 16 HOUR

Target

TARGET MONOAMINE REUPTAKE

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

Cyclobutanemethanamine, 1-(4-chlorophenyl)-alpha-(2-methylpropyl)-

Formula:
C15H22ClN

Calculated chemical properties:

MW 251.79
NB_atoms 17
XLogP 4.14
PSA 21.468
NB_HD 2
NB_HA 1
fsp3 0.60
Lipinski(0=no;1=yes) 1

FDA
-

Other links: