e-Drug3D

1660

M SIBUTRAMINE

INN
SIBUTRAMINE

(is an active metabolite)

cas 84467-54-9

CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

ROUTE (list)

-

ATC code

A08AA10

PK parameters

Tmax 3.5 HOUR
Cmax 25.4 NANOMOLAR
PPB 94 PERCENT
t1/2 16 HOUR

Target

TARGET MONOAMINE REUPTAKE

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

Cyclobutanemethanamine, 1-(4-chlorophenyl)-alpha-(2-methylpropyl)-

Formula:
C15H22ClN

Calculated chemical properties:

MW 251.79
NB_atoms 17
XLogP 4.14
PSA 21.468
NB_HD 2
NB_HA 1
fsp3 0.60
Lipinski(0=no;1=yes) 1

FDA
-

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

764

SIBUTRAMINE

DISCONTINUED

INN
SIBUTRAMINE

(has an active metabolite)

cas 106650-56-0

CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

ROUTE (list)

ORAL

ATC code

A08AA10

PK parameters

Tmax 1.2 HOUR
Cl 1750 LITER / HOUR
PPB 97 PERCENT
t1/2 1.1 HOUR

Solubility

2.9 MILLIGRAM / MILLILITER IN PH 5.2

Target

TARGET MONOAMINE REUPTAKE

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine

Formula:
C17H26ClN

Calculated chemical properties:

MW 279.84
NB_atoms 19
XLogP 4.74
PSA 2.419
NB_HD 0
NB_HA 1
fsp3 0.65
Lipinski(0=no;1=yes) 1

FDA
NDA 020632 (label) INN (SIBUTRAMINE HYDROCHLORIDE) MERIDIA (ABBOTT) APPROVAL= AP YEAR= 1997 DISCONTINUED

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

768

SIBUTRAMINE

DISCONTINUED

INN
SIBUTRAMINE

(has an active metabolite)

cas 106650-56-0

CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR

ROUTE (list)

ORAL

ATC code

A08AA10

PK parameters

Tmax 1.2 HOUR
Cl 1750 LITER / HOUR
PPB 97 PERCENT
t1/2 1.1 HOUR

Solubility

2.9 MILLIGRAM / MILLILITER IN PH 5.2

Target

TARGET MONOAMINE REUPTAKE

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine

Formula:
C17H26ClN

Calculated chemical properties:

MW 279.84
NB_atoms 19
XLogP 4.74
PSA 5.338
NB_HD 0
NB_HA 1
fsp3 0.65
Lipinski(0=no;1=yes) 1

FDA
NDA 020632 (label) INN (SIBUTRAMINE HYDROCHLORIDE) MERIDIA (ABBOTT) APPROVAL= AP YEAR= 1997 DISCONTINUED

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL