e-Drug3D

1657
M SIBUTRAMINE


INN
SIBUTRAMINE

(is an active metabolite)

cas 168835-59-4
CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR
ROUTE (list)

-

ATC code

A08AA10
PK parameters

Tmax 3.6 HOUR
Cmax 15 NANOMOLAR
PPB 94 PERCENT
t1/2 14 HOUR

Target

TARGET MONOAMINE REUPTAKE

 DrugCentral

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

 Download SDF file Cyclobutanemethanamine, 1-(4-chlorophenyl)-N-methyl-alpha-(2-methylpropyl)-

Formula:
C16H24ClN

Calculated chemical properties:

MW 265.81
NB_atoms 18
XLogP 4.40
PSA 8.206
NB_HD 1
NB_HA 1
fsp3 0.62
Lipinski(0=no;1=yes) 1

FDA
-

 Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL
e-Drug3D

764
SIBUTRAMINE

DISCONTINUED


INN
SIBUTRAMINE

(has an active metabolite)

cas 106650-56-0
CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR
ROUTE (list)

ORAL

ATC code

A08AA10
PK parameters

Tmax 1.2 HOUR
Cl 1750 LITER / HOUR
PPB 97 PERCENT
t1/2 1.1 HOUR

Solubility

2.9 MILLIGRAM / MILLILITER IN PH 5.2


 Target

TARGET MONOAMINE REUPTAKE

 DrugCentral

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

 Download SDF file 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine

Formula:
C17H26ClN

Calculated chemical properties:

MW 279.84
NB_atoms 19
XLogP 4.74
PSA 2.419
NB_HD 0
NB_HA 1
fsp3 0.65
Lipinski(0=no;1=yes) 1

FDA
NDA 020632 (label) INN (SIBUTRAMINE HYDROCHLORIDE) MERIDIA (ABBOTT) APPROVAL= AP YEAR= 1997 DISCONTINUED

 Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL
e-Drug3D

768
SIBUTRAMINE

DISCONTINUED


INN
SIBUTRAMINE

(has an active metabolite)

cas 106650-56-0
CLASS

METABOLISM
ANOREXIC
ANTIDEPRESSANT
ANTI-OBESITY
NOREPINEPHRINE, SEROTONIN AND DOPAMINE REUPTAKE INHIBITOR
ROUTE (list)

ORAL

ATC code

A08AA10
PK parameters

Tmax 1.2 HOUR
Cl 1750 LITER / HOUR
PPB 97 PERCENT
t1/2 1.1 HOUR

Solubility

2.9 MILLIGRAM / MILLILITER IN PH 5.2


 Target

TARGET MONOAMINE REUPTAKE

 DrugCentral

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

 Download SDF file 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine

Formula:
C17H26ClN

Calculated chemical properties:

MW 279.84
NB_atoms 19
XLogP 4.74
PSA 5.338
NB_HD 0
NB_HA 1
fsp3 0.65
Lipinski(0=no;1=yes) 1

FDA
NDA 020632 (label) INN (SIBUTRAMINE HYDROCHLORIDE) MERIDIA (ABBOTT) APPROVAL= AP YEAR= 1997 DISCONTINUED

 Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL