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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FOSNETUPITANT (has an active metabolite)
| FOSNETUPITANT | NERVOUS SYSTEM | INTRAVENOUS | Cmax 9.3 MICROMOLAR Tmax 0.5 HOUR VD 124 LITER PPB 92 PERCENT Cl 90 LITER / HOUR HT 0.96 HOUR SOLUBILITY IS PH DEPENDENT 11.5 MILLIGRAM PER MILLILITER AT PH 10 AND 1.4 MILLIGRAM PER MILLILITER PH 2 | Substance-P receptor UNIPROT P25103 TACR1 more at DrugCentral | EMA | ||||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NETUPITANT (is an active metabolite)
| NETUPITANT | NERVOUS SYSTEM | ORAL | Cmax 750.8 NANOMOLAR Tmax 5 HOUR VD 1982 LITER PPB 99.5 PERCENT Cl 20.3 LITER / HOUR HT 96 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | SUBSTANCE P/NEUROKININ 1 (NK1) RECEPTOR PDB 6HLP (CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST NETUPITANT) LIGAND CODE = GAW (link to the list of PDB complexes) Download experimental 3D coordinates of GAW with added hydrogens | Substance-P receptor UNIPROT P25103 TACR1 more at DrugCentral | EMA | |||
