FOSNETUPITANT (has an active metabolite) | FOSNETUPITANT | NERVOUS SYSTEM PRODRUG OF NETUPITANT A SUBSTANCE P/NEUROKININ 1 (NK1) RECEPTOR ANTAGONIST PREVENTION OF ACUTE AND DELAYED NAUSEA AND VOMITING ASSOCIATED WITH CANCER CHEMOTHERAPY | INTRAVENOUS | Cmax 9.3 MICROMOLAR Tmax 0.5 HOUR VD 124 LITER PPB 92 PERCENT Cl 90 LITER / HOUR HT 0.96 HOUR SOLUBILITY IS PH DEPENDENT 11.5 MILLIGRAM PER MILLILITER AT PH 10 AND 1.4 MILLIGRAM PER MILLILITER PH 2 | | GPCR NK1R_HUMAN ANTAGONIST P25103 | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |
NETUPITANT (is an active metabolite) | NETUPITANT | NERVOUS SYSTEM A SUBSTANCE P/NEUROKININ 1 (NK1) RECEPTOR ANTAGONIST PREVENTION OF ACUTE AND DELAYED NAUSE | ORAL | Cmax 750.8 NANOMOLAR Tmax 5 HOUR VD 1982 LITER PPB 99.5 PERCENT Cl 20.3 LITER / HOUR HT 96 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | SUBSTANCE P/NEUROKININ 1 (NK1) RECEPTOR PDB 6HLP (CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST NETUPITANT) LIGAND CODE = GAW (link to the list of PDB complexes) Download experimental 3D coordinates of GAW with added hydrogens | NEUROKININ 1 RECEPTOR ANTAGONIST CHEMBL249 NEUROKININ 1 RECEPTOR P25103 SUBSTANCE-P RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE NEUROKININ RECEPTOR | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |