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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M SOFOSBUVIR (is an active metabolite)
| SOFOSBUVIR |
ANTIINFECTIVES | - | Tmax 3 HOUR HT 27 HOUR | HEPATITIS C VIRUS (HCV) NUCLEOTIDE ANALOG NS5B POLYMERASE | NS5B protein UNIPROT Q8JXU8 NS5B -- Genome polyprotein UNIPROT P27958 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SOFOSBUVIR (has an active metabolite)
| SOFOSBUVIR |
ANTIINFECTIVES | ORAL | Tmax 1.25 HOUR PPB 63 PERCENT HT 0.4 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | HEPATITIS C VIRUS (HCV) NUCLEOTIDE ANALOG NS5B POLYMERASE PDB 8FHS (HUMAN L-TYPE VOLTAGE-GATED CALCIUM CHANNEL CAV1.2 IN THE PRESENCE OF AMIODARONE AND SOFOSBUVIR AT 3.3 ANGSTROM RESOLUTION) LIGAND CODE = WG6 (link to the list of PDB complexes) Download experimental 3D coordinates of WG6 with added hydrogens | NS5B protein UNIPROT Q8JXU8 NS5B -- Genome polyprotein UNIPROT P27958 more at DrugCentral | EMA | |||
