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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M FLUOROURACIL (is an active metabolite)
| FLUOROURACIL | ANTINEOPLASTIC | - | DNA PDB 5WNY (DNA POLYMERASE BETA SUBSTRATE COMPLEX WITH INCOMING 5-FDUTP) LIGAND CODE = B7P (link to the list of PDB complexes) Download experimental 3D coordinates of B7P with added hydrogens | Thymidylate synthase UNIPROT P04818 TYMS more at DrugCentral | EMA | ||||
