PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
CARDIOVASCULAR ANTIHYPERTENSIVE CANDESARTAN IS A SELECTIVE AT1 SUBTYPE ANGIOTENSIN II RECEPTOR ANTAGONIST CANDESARTAN BLOCKS THE VASOCONSTRICTOR AND ALDOSTERONE-SECRETING EFFECTS OF ANGIOTENSIN II
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F 15 PERCENT
VD 8.4 LITER (65 KILOGRAM)
PPB 99 PERCENT
Cl 1.4 LITER / HOUR (65 KILOGRAM)
HT 9 HOUR
ANGIOTENSIN II RECEPTOR AT1
Type-1 angiotensin II receptor UNIPROT P30556 AGTR1
PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
CARDIOVASCULAR ANTIHYPERTENSIVE HYDROLYZED TO CANDESARTAN DURING ABSORPTION FROM THE GASTROINTESTINAL TRACT CANDESARTAN IS A SELECTIVE AT1 SUBTYPE ANGIOTENSIN II RECEPTOR ANTAGONIST CANDESARTAN BLOCKS THE VASOCONSTRICTOR AND ALDOSTERONE-SECRETING EFFECTS OF ANGIOTENSIN II
ORAL
SOLUBILITY PRACTICALLY INSOLUBLE IN WATER
ANGIOTENSIN II RECEPTOR AT1
Type-1 angiotensin II receptor UNIPROT P30556 AGTR1
PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
CARDIOVASCULAR ANTIHYPERTENSIVE HYDROLYZED TO CANDESARTAN DURING ABSORPTION FROM THE GASTROINTESTINAL TRACT CANDESARTAN IS A SELECTIVE AT1 SUBTYPE ANGIOTENSIN II RECEPTOR ANTAGONIST CANDESARTAN BLOCKS THE VASOCONSTRICTOR AND ALDOSTERONE-SECRETING EFFECTS OF ANGIOTENSIN II
ORAL
SOLUBILITY PRACTICALLY INSOLUBLE IN WATER
ANGIOTENSIN II RECEPTOR AT1
Type-1 angiotensin II receptor UNIPROT P30556 AGTR1