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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DESVENLAFAXINE (is an active metabolite)
| DESVENLAFAXINE | NERVOUS SYSTEM | ORAL | Cmax 1.1 MICROMOLAR Tmax 3 HOUR F 80 PERCENT VD 370 LITER (65 KILOGRAM) PPB 30 PERCENT Cl 26 LITER / HOUR (65 KILOGRAM) HT 11 HOUR SOLUBILITY SOLUBLE IN WATER PH DEPENDENT | SEROTONIN AND NOREPINEPHRINE REUPTAKE | NOREPINEPHRINE TRANSPORTER INHIBITOR CHEMBL222 NOREPINEPHRINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06 | ANSM (in French) | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DESVENLAFAXINE (is an active metabolite)
| DESVENLAFAXINE | NERVOUS SYSTEM | ORAL | Cmax 1.1 MICROMOLAR Tmax 3 HOUR F 80 PERCENT VD 370 LITER (65 KILOGRAM) PPB 30 PERCENT Cl 26 LITER / HOUR (65 KILOGRAM) HT 11 HOUR SOLUBILITY SOLUBLE IN WATER PH DEPENDENT | SEROTONIN AND NOREPINEPHRINE REUPTAKE PDB 4MMC (CRYSTAL STRUCTURE OF LEUBAT (DELTA6 MUTANT) IN COMPLEX WITH DESVENLAFAXINE) LIGAND CODE = 29J (link to the list of PDB complexes) Download experimental 3D coordinates of 29J with added hydrogens | NOREPINEPHRINE TRANSPORTER INHIBITOR CHEMBL222 NOREPINEPHRINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06 | ANSM (in French) | |||
| 3 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VENLAFAXINE (has an active metabolite)
| VENLAFAXINE | NERVOUS SYSTEM | ORAL | Cmax 812 NANOMOLAR Tmax 2 HOUR F 92 PERCENT VD 487 LITER (65 KILOGRAM) PPB 27 PERCENT Cl 84.5 LITER / HOUR (65 KILOGRAM) HT 5 HOUR SOLUBILITY 572 MILLIGRAM / MILLILITER IN WATER (LOGP 0.43) | SEROTONIN REUPTAKE TRANSPORTER | NOREPINEPHRINE TRANSPORTER INHIBITOR CHEMBL222 NOREPINEPHRINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06 | ANSM (in French) | |||
