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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DESVENLAFAXINE (is an active metabolite)
| DESVENLAFAXINE | NERVOUS SYSTEM | ORAL | Cmax 1.1 MICROMOLAR Tmax 3 HOUR F 80 PERCENT VD 370 LITER (65 KILOGRAM) PPB 30 PERCENT Cl 26 LITER / HOUR (65 KILOGRAM) HT 11 HOUR SOLUBILITY SOLUBLE IN WATER PH DEPENDENT | SEROTONIN AND NOREPINEPHRINE REUPTAKE | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VENLAFAXINE (has an active metabolite)
| VENLAFAXINE | NERVOUS SYSTEM | ORAL | Cmax 812 NANOMOLAR Tmax 2 HOUR F 92 PERCENT VD 487 LITER (65 KILOGRAM) PPB 27 PERCENT Cl 84.5 LITER / HOUR (65 KILOGRAM) HT 5 HOUR SOLUBILITY 572 MILLIGRAM / MILLILITER IN WATER (LOGP 0.43) | SEROTONIN REUPTAKE TRANSPORTER PDB 8F4W (CRYSTAL STRUCTURE OF ACETYLTRANSFERASE EIS FROM M. TUBERCULOSIS IN COMPLEX WITH VENLAFAXINE) LIGAND CODE = VFX (link to the list of PDB complexes) Download experimental 3D coordinates of VFX with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
| 3 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VENLAFAXINE (has an active metabolite)
| VENLAFAXINE | NERVOUS SYSTEM | ORAL | Cmax 812 NANOMOLAR Tmax 2 HOUR F 92 PERCENT VD 487 LITER (65 KILOGRAM) PPB 27 PERCENT Cl 84.5 LITER / HOUR (65 KILOGRAM) HT 5 HOUR SOLUBILITY 572 MILLIGRAM / MILLILITER IN WATER (LOGP 0.43) | SEROTONIN REUPTAKE TRANSPORTER | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
