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session 2030 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HALAZEPAM DISCONTINUED (has an active metabolite)

HALAZEPAM


ATC N05BA13

NERVOUS SYSTEM
ANXIOLYTIC
BENZODIAZEPINES
MUSCLE RELAXANTS
SEDATIVE
PRECUSOR OF DESMETHYLDIAZEPAM (PMID6123659)

ORAL

VD 732 LITER (EQN)

Cl 24 LITER / HOUR (PMID1980307)

HT 21.15 HOUR

GAMMA-AMINOBUTYRIC-ACID RECEPTOR

GABA-A receptor

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M DIAZEPAM (is an active metabolite) (has an active metabolite)

DIAZEPAM


ATC N05BA01

NERVOUS SYSTEM
ANXIOLYTIC
BENZODIAZEPINES
MUSCLE RELAXANTS
SEDATIVE

-

VD 29.2 LITER (65 KILOGRAM)

PPB 97 PERCENT

Cl 0.46 LITER / HOUR (65 KILOGRAM)

HT 46 HOUR

GAMMA-AMINOBUTYRIC-ACID RECEPTOR

GABA A receptor alpha-5,beta-2,gamma-3 UNIPROT P31644 GABRA5 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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