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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AZATHIOPRINE (has an active metabolite)

AZATHIOPRINE


ATC L04AX01

ANTINEOPLASTIC
IMMUNOSUPPRESSIVE ANTIMETABOLITES
ANTIRHEUMATIC AGENTS
AZATHIOPRINE IS METABOLIZED TO 6-MERCAPTOPURINE (6-MP) AND THEN BY HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) AND DIVERSES KINASES WHICH LEAD TO THE INCORPORATION OF 6-THIOGUANINE NUCLEOTIDES (6-TGN) INTO DNA

ORAL INJECTION

Tmax 1.5 HOUR

PPB 30 PERCENT

SOLUBILITY INSOLUBLE IN WATER

DNA

HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE HOMO SAPIENS ENZYMEANSM (in French)

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