Browse e-DRUG3D database

Cheminformatic Tools and Databases for Pharmacology
Home	e-Drug3D	LEA3D	SENSAAS	IPMC

session 4653 - Total of 2 hits - Display hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)


1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
AZATHIOPRINE (has an active metabolite)	AZATHIOPRINE	ATC L04AX01 ANTINEOPLASTIC IMMUNOSUPPRESSIVE ANTIMETABOLITES ANTIRHEUMATIC AGENTS AZATHIOPRINE IS METABOLIZED TO 6-MERCAPTOPURINE (6-MP) AND THEN BY HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) AND DIVERSES KINASES WHICH LEAD TO THE INCORPORATION OF 6-THIOGUANINE NUCLEOTIDES (6-TGN) INTO DNA	ORAL INJECTION	Tmax 1.5 HOUR PPB 30 PERCENT SOLUBILITY INSOLUBLE IN WATER	DNA	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE HOMO SAPIENS ENZYME	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
MERCAPTOPURINE (is an active metabolite)	MERCAPTOPURINE	ATC L01BB02 ANTINEOPLASTIC TREATMENT OF ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) (DRUG FOR RARE DISEASE IN EUROPE) ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS NUCLEIC ACID SYNTHESIS INHIBITORS PURINE ANALOGUES MODIFIED BY HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) TO TIMP (THIOINOSINE MONOPHOSPHATE) AND THEN DIVERSES KINASES (INOSINE MONOPHOSPHATE DEHYDROGENASE, GUANOSINE MONOPHOSPHATE SYNTHETASE AND KINASES) WHICH LEAD TO THE INCORPORATION OF 6-THIOGUANINE NUCLEOTIDES (6-TGN) INTO DNA	ORAL	VD 65 LITER (65 KILOGRAM) PPB 15 PERCENT Cl 58.5 LITER / HOUR (65 KILOGRAM) HT 1 HOUR	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT)	DNA INHIBITOR CHEMBL2311221 DNA Q06203 AMIDOPHOSPHORIBOSYLTRANSFERASE HOMO SAPIENS ENZYME TRANSFERASE	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank