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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CAPECITABINE (has an active metabolite)
| CAPECITABINE | ANTINEOPLASTIC | ORAL | Tmax 1.5 HOUR PPB 60 PERCENT HT 0.75 HOUR SOLUBILITY 26 MILLIGRAM / MILLILITER | CARBOXYLESTERASE | Thymidylate synthase UNIPROT P04818 TYMS more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLOXURIDINE (has an active metabolite)
| FLOXURIDINE | ANTINEOPLASTIC | INJECTION | SOLUBILITY FREELY SOLUBLE IN WATER | URIDINE 5-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) PDB 2QCF (CRYSTAL STRUCTURE OF THE OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASE DOMAIN (ASP312ASN MUTANT) OF HUMAN UMP SYNTHASE BOUND TO 5-FLUORO-UMP) LIGAND CODE = 5FU (link to the list of PDB complexes) Download experimental 3D coordinates of 5FU with added hydrogens | Thymidylate synthase UNIPROT P04818 TYMS more at DrugCentral | EMA | |||
| 3 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLUCYTOSINE (has an active metabolite)
| FLUCYTOSINE | ANTIINFECTIVES | ORAL | Cmax 271.3 MICROMOLAR Tmax 2 HOUR F 83 PERCENT VD 44.2 LITER (65 KILOGRAM) PPB 4 PERCENT Cl 7.8 LITER / HOUR (65 KILOGRAM) HT 3.6 HOUR | CYTOSINE DEAMINASE | Thymidylate synthase UNIPROT P0CS13 TMP1 -- Thymidylate synthase UNIPROT P12461 TMP1 more at DrugCentral | EMA | |||
| 4 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLUOROURACIL (is an active metabolite) (has an active metabolite)
| FLUOROURACIL | ANTINEOPLASTIC | INJECTION TOPICAL | Cmax 88.3 NANOMOLAR Tmax 1.03 HOUR VD 14.9 LITER (65 KILOGRAM) PPB 85 PERCENT Cl 101.4 LITER / HOUR (65 KILOGRAM) HT 0.12 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | THYMIDYLATE SYNTHASE PDB 3KVR (TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS) LIGAND CODE = URF (link to the list of PDB complexes) Download experimental 3D coordinates of URF with added hydrogens | Thymidylate synthase UNIPROT P04818 TYMS more at DrugCentral | EMA | |||
| 5 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M FLUOROURACIL (is an active metabolite)
| FLUOROURACIL | ANTINEOPLASTIC | - | THYMIDYLATE SYNTHASE (TS) PDB 3H9K (STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY) LIGAND CODE = UFP (link to the list of PDB complexes) Download experimental 3D coordinates of UFP with added hydrogens | Thymidylate synthase UNIPROT P04818 TYMS more at DrugCentral | EMA | ||||
| 6 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M FLUOROURACIL (is an active metabolite)
| FLUOROURACIL | ANTINEOPLASTIC | - | DNA PDB 5WNY (DNA POLYMERASE BETA SUBSTRATE COMPLEX WITH INCOMING 5-FDUTP) LIGAND CODE = B7P (link to the list of PDB complexes) Download experimental 3D coordinates of B7P with added hydrogens | Thymidylate synthase UNIPROT P04818 TYMS more at DrugCentral | EMA | ||||
