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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FEXINIDAZOLE (has an active metabolite)

FEXINIDAZOLE


ATC P01CA03

ANTIPARASITIC
ANTIPROTOZOAL
NITROIMIDAZOLE ANTIMICROBIAL
TREATMENT OF HUMAN AFRICAN TRYPANOSOMIASIS (HAT) DUE TO TRYPANOSOMA BRUCEI GAMBIENSE

ORAL

Cmax 2.9 MICROMOLAR

Tmax 4 HOUR

VD 3222 LITER

PPB 98 PERCENT

Cl 161 LITER / HOUR

HT 15 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

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