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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FOSNETUPITANT (has an active metabolite)

FOSNETUPITANT

NERVOUS SYSTEM
PRODRUG OF NETUPITANT
A SUBSTANCE P/NEUROKININ 1 (NK1) RECEPTOR ANTAGONIST
PREVENTION OF ACUTE AND DELAYED NAUSEA AND VOMITING ASSOCIATED WITH CANCER CHEMOTHERAPY

INTRAVENOUS

Cmax 9.3 MICROMOLAR

Tmax 0.5 HOUR

VD 124 LITER

PPB 92 PERCENT

Cl 90 LITER / HOUR

HT 0.96 HOUR

SOLUBILITY IS PH DEPENDENT 11.5 MILLIGRAM PER MILLILITER AT PH 10 AND 1.4 MILLIGRAM PER MILLILITER PH 2

GPCR NK1R_HUMAN ANTAGONIST P25103ANSM (in French)

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