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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TELOTRISTAT (is an active metabolite)

TELOTRISTAT


ATC A16AX15

METABOLISM
TREATMENT OF CARCINOID SYNDROME DIARRHEA
TRYPTOPHAN HYDROXYLASE INHIBITOR WHICH MEDIATES THE RATE LIMITING STEP IN SEROTONIN BIOSYNTHESIS

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Cmax 1.1 MICROMOLAR

Tmax 2 HOUR

PPB 99 PERCENT

Cl 152 LITER / HOUR

HT 5 HOUR

TRYPTOPHAN HYDROXYLASE

ENZYME TPH1_HUMAN INHIBITOR UNIPROT P17752

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