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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TELOTRISTAT (is an active metabolite)
| TELOTRISTAT | METABOLISM | - | Cmax 1.1 MICROMOLAR Tmax 2 HOUR PPB 99 PERCENT Cl 152 LITER / HOUR HT 5 HOUR | TRYPTOPHAN HYDROXYLASE | ENZYME TPH1_HUMAN INHIBITOR UNIPROT P17752 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TELOTRISTAT ETHYL (has an active metabolite)
| TELOTRISTAT ETHYL | METABOLISM | ORAL | Cmax 7.6 NANOMOLAR Tmax 1.25 HOUR PPB 99 PERCENT Cl 2.7 LITER / HOUR HT 0.6 HOUR SOLUBILITY NEGLIGIBLE AT A PH OF 5 TO 9 | TRYPTOPHAN HYDROXYLASE | Tryptophan 5-hydroxylase 1 UNIPROT P17752 TPH1 more at DrugCentral | EMA | |||
