Cheminformatic Tools and Databases for Pharmacology

session 55969 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IXAZOMIB (is an active metabolite)

IXAZOMIB


ATC L01XX50

ANTINEOPLASTIC
TREATMENT OF MULTIPLE MYELOMA
PROTEASOME INHIBITOR
PRODRUG OF IXAZOMIB
CHYMOTRYPSIN-LIKE ACTIVITY OF THE BETA 5 SUBUNIT OF THE 20S PROTEASOME

-

Tmax 1 HOUR

F 58 PERCENT

VD 543 LITER

PPB 99 PERCENT

Cl 1.9 LITER / HOUR

HT 228 HOUR

20S PROTEASOME

PDB 5LF7 (HUMAN 20S PROTEASOME COMPLEX WITH IXAZOMIB AT 2.0 ANGSTROM)

LIGAND CODE = 6V8 (link to the list of PDB complexes)

Download experimental 3D coordinates of 6V8 with added hydrogens

ENZYME PSB5_HUMAN INHIBITOR P28074ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IXAZOMIB CITRATE (has an active metabolite)

IXAZOMIB CITRATE


ATC L01XX50

ANTINEOPLASTIC
TREATMENT OF MULTIPLE MYELOMA
PROTEASOME INHIBITOR
PRODRUG OF IXAZOMIB
CHYMOTRYPSIN-LIKE ACTIVITY OF THE BETA 5 SUBUNIT OF THE 20S PROTEASOME

ORAL 20S PROTEASOME

ENZYME PSB5_HUMAN INHIBITOR P28074ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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