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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IXAZOMIB (is an active metabolite)
| IXAZOMIB | ANTINEOPLASTIC | - | Tmax 1 HOUR F 58 PERCENT VD 543 LITER PPB 99 PERCENT Cl 1.9 LITER / HOUR HT 228 HOUR | 20S PROTEASOME PDB 5LF7 (HUMAN 20S PROTEASOME COMPLEX WITH IXAZOMIB AT 2.0 ANGSTROM) LIGAND CODE = 6V8 (link to the list of PDB complexes) Download experimental 3D coordinates of 6V8 with added hydrogens | Proteasome subunit beta type-5 UNIPROT P28074 PSMB5 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IXAZOMIB CITRATE (has an active metabolite)
| IXAZOMIB CITRATE | ANTINEOPLASTIC | ORAL | 20S PROTEASOME | Proteasome subunit beta type-5 UNIPROT P28074 PSMB5 more at DrugCentral | EMA | ||||
