Cheminformatic Tools and Databases for Pharmacology

session 67415 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TEDIZOLID (is an active metabolite)

TEDIZOLID


ATC J01XX11

ANTIINFECTIVES
ANTIBACTERIAL AGENT OF THE OXAZOLIDINONE
BINDING TO THE 50S SUBUNIT OF THE BACTERIAL RIBOSOME

-

Cmax 8.1 MICROMOLAR

Tmax 1.2 HOUR

F 91 PERCENT

VD 73.5 LITER

PPB 80 PERCENT

Cl 5.9 LITER / HOUR

HT 12 HOUR

RIBOSOME 50S SUBUNIT

PDB 6WRS (STRUCTURE OF THE 50S SUBUNIT OF THE RIBOSOME FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN COMPLEX WITH THE ANTIBIOTIC, TEDIZOLID)

LIGAND CODE = U7V (link to the list of PDB complexes)

Download experimental 3D coordinates of U7V with added hydrogens

BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL2363135 BACTERIAL 70S RIBOSOME 23S RIBOSOMAL RNA BACTERIAANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TEDIZOLID PHOSPHATE (has an active metabolite)

TEDIZOLID PHOSPHATE


ATC J01XX11

ANTIINFECTIVES
ANTIBACTERIAL AGENT OF THE OXAZOLIDINONE
BINDING TO THE 50S SUBUNIT OF THE BACTERIAL RIBOSOME
PRODRUG OF TEDIZOLID

ORAL INTRAVENOUS RIBOSOME 50S SUBUNIT

BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL2363135 BACTERIAL 70S RIBOSOME 23S RIBOSOMAL RNA BACTERIAANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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