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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M TAMOXIFEN (is an active metabolite)
| TAMOXIFEN | ANTINEOPLASTIC | - | Cmax 941 NANOMOLAR HT 336 HOUR | ESTROGEN RECEPTOR PDB 6Z8C (CRYSTAL STRUCTURE OF THE VOLTAGE-GATED SODIUM CHANNEL NAVMS (F208L) IN COMPLEX WITH N-DESMETHYLTAMOXIFEN (3.2 A RESOLUTION)) LIGAND CODE = QBN (link to the list of PDB complexes) Download experimental 3D coordinates of QBN with added hydrogens | Estrogen receptor UNIPROT P03372 ESR1 more at DrugCentral | EMA | |||
