| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M TAMOXIFEN (is an active metabolite)
| TAMOXIFEN | ANTINEOPLASTIC | - | Cmax 941 NANOMOLAR HT 336 HOUR | ESTROGEN RECEPTOR PDB 6Z8C (CRYSTAL STRUCTURE OF THE VOLTAGE-GATED SODIUM CHANNEL NAVMS (F208L) IN COMPLEX WITH N-DESMETHYLTAMOXIFEN (3.2 A RESOLUTION)) LIGAND CODE = QBN (link to the list of PDB complexes) Download experimental 3D coordinates of QBN with added hydrogens | Estrogen receptor UNIPROT P03372 ESR1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TAMOXIFEN (has an active metabolite)
| TAMOXIFEN | ANTINEOPLASTIC | ORAL | Cmax 323 NANOMOLAR Tmax 5 HOUR PPB 99 PERCENT HT 144 HOUR SOLUBILITY IN WATER AT 37 DEGREE CELCIUS IS 0.5 MILLIGRAM / MILLILITER | ESTROGEN RECEPTOR PDB 1YA4 (CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE 1 IN COMPLEX WITH TAMOXIFEN) LIGAND CODE = CTX (link to the list of PDB complexes) Download experimental 3D coordinates of CTX with added hydrogens | Estrogen receptor UNIPROT P03372 ESR1 more at DrugCentral | EMA | |||
