Cheminformatic Tools and Databases for Pharmacology

session 73359 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
APROCITENTAN (is an active metabolite)

APROCITENTAN


ATC C02KN01

CARDIOVASCULAR
ANTIHYPERTENSIVE
PULMONARY ARTERIAL HYPERTENSION (PAH)
ENDOTHELIN RECEPTOR ANTAGONIST ET-1
PREVENTS THE BINDING OF ET-1 TO ITS RECEPTORS ETA AND ETB
METABOLITE 20 PERCENT AS POTENT AS THE PARENT DRUG IN VITRO

ORAL

Cmax 2.38 MICROMOLAR

Tmax 4.5 HOUR

VD 20 LITER

PPB 99 PERCENT

Cl 0.3 LITER / HOUR

HT 41 HOUR

SOLUBILITY INSOLUBLE IN WATER

ENDOTHELIN RECEPTOR ET-1

-

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |