PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
CARDIOVASCULAR ANTIHYPERTENSIVE PULMONARY ARTERIAL HYPERTENSION (PAH) ENDOTHELIN RECEPTOR ANTAGONIST ET-1 PREVENTS THE BINDING OF ET-1 TO ITS RECEPTORS ETA AND ETB
ORAL
VD 50 LITER
PPB 99 PERCENT
Cl 2.1 LITER / HOUR (EQN)
HT 16 HOUR
SOLUBILITY NOT SOLUBLE IN WATER
ENDOTHELIN RECEPTOR ET-1
ENDOTHELIN RECEPTOR, ET-A/ET-B ANTAGONIST CHEMBL2096678 ENDOTHELIN RECEPTOR, ET-A/ET-B P24530 ENDOTHELIN B RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE ENDOTHELIN RECEPTOR
PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
CARDIOVASCULAR ANTIHYPERTENSIVE PULMONARY ARTERIAL HYPERTENSION (PAH) ENDOTHELIN RECEPTOR ANTAGONIST ET-1 PREVENTS THE BINDING OF ET-1 TO ITS RECEPTORS ETA AND ETB METABOLITE 20 PERCENT AS POTENT AS THE PARENT DRUG IN VITRO
-
VD 40 LITER
PPB 99 PERCENT
Cl 0.6 LITER / HOUR (EQN)
HT 48 HOUR
ENDOTHELIN RECEPTOR ET-1
ENDOTHELIN RECEPTOR, ET-A/ET-B ANTAGONIST CHEMBL2096678 ENDOTHELIN RECEPTOR, ET-A/ET-B P24530 ENDOTHELIN B RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE ENDOTHELIN RECEPTOR