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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MACITENTAN (has an active metabolite)
| MACITENTAN | CARDIOVASCULAR | ORAL | VD 50 LITER PPB 99 PERCENT Cl 2.1 LITER / HOUR (EQN) HT 16 HOUR SOLUBILITY NOT SOLUBLE IN WATER | ENDOTHELIN RECEPTOR ET-1 | ENDOTHELIN RECEPTOR, ET-A/ET-B ANTAGONIST CHEMBL2096678 ENDOTHELIN RECEPTOR, ET-A/ET-B P24530 ENDOTHELIN B RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE ENDOTHELIN RECEPTOR | ANSM (in French) | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M MACITENTAN (is an active metabolite)
| MACITENTAN | CARDIOVASCULAR | - | VD 40 LITER PPB 99 PERCENT Cl 0.6 LITER / HOUR (EQN) HT 48 HOUR | ENDOTHELIN RECEPTOR ET-1 | ENDOTHELIN RECEPTOR, ET-A/ET-B ANTAGONIST CHEMBL2096678 ENDOTHELIN RECEPTOR, ET-A/ET-B P24530 ENDOTHELIN B RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE ENDOTHELIN RECEPTOR | ANSM (in French) | |||
