PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used
Primary Target and PDB code of Protein-Drug complex
CARDIOVASCULAR ANTIHYPERTENSIVE PULMONARY ARTERIAL HYPERTENSION (PAH) ENDOTHELIN RECEPTOR ANTAGONIST ET-1 PREVENTS THE BINDING OF ET-1 TO ITS RECEPTORS ETA AND ETB METABOLITE 20 PERCENT AS POTENT AS THE PARENT DRUG IN VITRO
PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used
Primary Target and PDB code of Protein-Drug complex
CARDIOVASCULAR ANTIHYPERTENSIVE PULMONARY ARTERIAL HYPERTENSION (PAH) ENDOTHELIN RECEPTOR ANTAGONIST ET-1 PREVENTS THE BINDING OF ET-1 TO ITS RECEPTORS ETA AND ETB