Cheminformatic Tools and Databases for Pharmacology

session 18557 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FINGOLIMOD (has an active metabolite)

FINGOLIMOD


ATC L04AA27

IMMUNOMODULATING
IMMUNOSUPPRESSANT
MULTIPLE SCLEROSIS
FINGOLIMOD IS METABOLIZED BY SPHINGOSINE KINASE TO THE ACTIVE METABOLITE FINGOLIMOD-PHOSPHATE
FINGOLIMOD-PHOSPHATE INVOLVES REDUCTION OF LYMPHOCYTE MIGRATION INTO THE CENTRAL NERVOUS SYSTEM
S1P1 MODULATOR (RECEPTOR DEGRADATION VERSUS RECYCLING TO CELL SURFACE)

ORAL

F 93 PERCENT

PPB 99.7 PERCENT

SOLUBILITY FREELY SOLUBLE IN WATER

SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P1)

SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST CHEMBL2363041 SPHINGOSINE 1-PHOSPHATE RECEPTOR O95136 SPHINGOSINE 1-PHOSPHATE RECEPTOR 2 HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL LIPID-LIKE LIGAND RECEPTOR EDG RECEPTORANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M FINGOLIMOD (is an active metabolite)

FINGOLIMOD


ATC L04AA27

IMMUNOMODULATING
IMMUNOSUPPRESSANT
MULTIPLE SCLEROSIS
FINGOLIMOD IS METABOLIZED BY SPHINGOSINE KINASE TO THE ACTIVE METABOLITE FINGOLIMOD-PHOSPHATE
FINGOLIMOD-PHOSPHATE INVOLVES REDUCTION OF LYMPHOCYTE MIGRATION INTO THE CENTRAL NERVOUS SYSTEM
S1P1 MODULATOR (NOT ANTAGONIST BUT AN AGONIST THAT CAUSES RECEPTOR DEGRADATION VERSUS RECYCLING TO CELL SURFACE)

-

F 93 PERCENT

VD 1200 LITER

PPB 99.7 PERCENT

Cl 6.3 LITER / HOUR

HT 180 HOUR

SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P1)

SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST CHEMBL2363041 SPHINGOSINE 1-PHOSPHATE RECEPTOR O95136 SPHINGOSINE 1-PHOSPHATE RECEPTOR 2 HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL LIPID-LIKE LIGAND RECEPTOR EDG RECEPTORANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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