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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
FINGOLIMOD (has an active metabolite)	FINGOLIMOD	ATC L04AE01 IMMUNOMODULATING IMMUNOSUPPRESSANT MULTIPLE SCLEROSIS FINGOLIMOD IS METABOLIZED BY SPHINGOSINE KINASE TO THE ACTIVE METABOLITE FINGOLIMOD-PHOSPHATE FINGOLIMOD-PHOSPHATE INVOLVES REDUCTION OF LYMPHOCYTE MIGRATION INTO THE CENTRAL NERVOUS SYSTEM S1P1 MODULATOR (RECEPTOR DEGRADATION VERSUS RECYCLING TO CELL SURFACE)	ORAL	F 93 PERCENT PPB 99.7 PERCENT SOLUBILITY FREELY SOLUBLE IN WATER	SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P1)	Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M FINGOLIMOD (is an active metabolite)	FINGOLIMOD	ATC L04AE01 IMMUNOMODULATING IMMUNOSUPPRESSANT MULTIPLE SCLEROSIS FINGOLIMOD IS METABOLIZED BY SPHINGOSINE KINASE TO THE ACTIVE METABOLITE FINGOLIMOD-PHOSPHATE FINGOLIMOD-PHOSPHATE INVOLVES REDUCTION OF LYMPHOCYTE MIGRATION INTO THE CENTRAL NERVOUS SYSTEM S1P1 MODULATOR (NOT ANTAGONIST BUT AN AGONIST THAT CAUSES RECEPTOR DEGRADATION VERSUS RECYCLING TO CELL SURFACE)	-	F 93 PERCENT VD 1200 LITER PPB 99.7 PERCENT Cl 6.3 LITER / HOUR HT 180 HOUR	SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P1) PDB 7VIF (CRYO-EM STRUCTURE OF GI COUPLED SPHINGOSINE 1-PHOSPHATE RECEPTOR BOUND WITH (S)-FTY720-P) LIGAND CODE = J89 (link to the list of PDB complexes) Download experimental 3D coordinates of J89 with added hydrogens	Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank