PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
IMMUNOMODULATING IMMUNOSUPPRESSANT MULTIPLE SCLEROSIS FINGOLIMOD IS METABOLIZED BY SPHINGOSINE KINASE TO THE ACTIVE METABOLITE FINGOLIMOD-PHOSPHATE FINGOLIMOD-PHOSPHATE INVOLVES REDUCTION OF LYMPHOCYTE MIGRATION INTO THE CENTRAL NERVOUS SYSTEM S1P1 MODULATOR (RECEPTOR DEGRADATION VERSUS RECYCLING TO CELL SURFACE)
PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
IMMUNOMODULATING IMMUNOSUPPRESSANT MULTIPLE SCLEROSIS FINGOLIMOD IS METABOLIZED BY SPHINGOSINE KINASE TO THE ACTIVE METABOLITE FINGOLIMOD-PHOSPHATE FINGOLIMOD-PHOSPHATE INVOLVES REDUCTION OF LYMPHOCYTE MIGRATION INTO THE CENTRAL NERVOUS SYSTEM S1P1 MODULATOR (NOT ANTAGONIST BUT AN AGONIST THAT CAUSES RECEPTOR DEGRADATION VERSUS RECYCLING TO CELL SURFACE)