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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M SAXAGLIPTIN (is an active metabolite)

SAXAGLIPTIN


ATC A10BH03
ATC A10BD10
ATC A10BD25
ATC A10BD21

ANTIDIABETIC
DIPEPTIDYL-PEPTIDASE IV INHIBITOR
HYPOGLYCEMIC AGENTS
TYPE 2 DIABETES MELLITUS
METABOLISM
METABOLITE OF SAXAGLIPTIN IS ONE-HALF AS POTENT AS SAXAGLIPTIN AS DPP4 INHIBITOR

-

Cmax 149 NANOMOLAR (5 MILLIGRAM)

VD 61 LITER (EQN)

PPB 0 PERCENT

Cl 13.8 LITER / HOUR

HT 3.1 HOUR

DIPEPTIDYL PEPTIDASE-4 (DPP-4)

DIPEPTIDYL PEPTIDASE IV INHIBITOR CHEMBL284 DIPEPTIDYL PEPTIDASE IV P27487 DIPEPTIDYL PEPTIDASE 4 HOMO SAPIENS ENZYME PROTEASE SERINE SC S9BANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SAXAGLIPTIN (has an active metabolite)

SAXAGLIPTIN


ATC A10BH03
ATC A10BD21
ATC A10BD10
ATC A10BD25

ANTIDIABETIC
DIPEPTIDYL-PEPTIDASE IV INHIBITOR
HYPOGLYCEMIC AGENTS
TYPE 2 DIABETES MELLITUS
METABOLISM
METABOLITE OF SAXAGLIPTIN IS ONE-HALF AS POTENT AS SAXAGLIPTIN AS DPP4 INHIBITOR

ORAL

Cmax 76 NANOMOLAR (5 MILLIGRAM)

VD 49.7 LITER (EQN)

PPB 0 PERCENT

Cl 13.8 LITER / HOUR

HT 2.5 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

DIPEPTIDYL PEPTIDASE-4 (DPP-4)

DIPEPTIDYL PEPTIDASE IV INHIBITOR CHEMBL284 DIPEPTIDYL PEPTIDASE IV P27487 DIPEPTIDYL PEPTIDASE 4 HOMO SAPIENS ENZYME PROTEASE SERINE SC S9BANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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