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session 17404 - Total of 2 hits - Display hits per page:

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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M SAXAGLIPTIN (is an active metabolite)	SAXAGLIPTIN	ATC A10BD10 ATC A10BD25 ATC A10BH03 ATC A10BD21 ANTIDIABETIC DIPEPTIDYL-PEPTIDASE IV INHIBITOR HYPOGLYCEMIC AGENTS TYPE 2 DIABETES MELLITUS METABOLISM METABOLITE OF SAXAGLIPTIN IS ONE-HALF AS POTENT AS SAXAGLIPTIN AS DPP4 INHIBITOR	-	Cmax 149 NANOMOLAR (5 MILLIGRAM) VD 61 LITER (EQN) PPB 0 PERCENT Cl 13.8 LITER / HOUR HT 3.1 HOUR	DIPEPTIDYL PEPTIDASE-4 (DPP-4)	Dipeptidyl peptidase 4 UNIPROT P27487 DPP4 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
SAXAGLIPTIN (has an active metabolite)	SAXAGLIPTIN	ATC A10BD10 ATC A10BD25 ATC A10BH03 ATC A10BD21 ANTIDIABETIC DIPEPTIDYL-PEPTIDASE IV INHIBITOR HYPOGLYCEMIC AGENTS TYPE 2 DIABETES MELLITUS METABOLISM METABOLITE OF SAXAGLIPTIN IS ONE-HALF AS POTENT AS SAXAGLIPTIN AS DPP4 INHIBITOR	ORAL	Cmax 76 NANOMOLAR (5 MILLIGRAM) VD 49.7 LITER (EQN) PPB 0 PERCENT Cl 13.8 LITER / HOUR HT 2.5 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER	DIPEPTIDYL PEPTIDASE-4 (DPP-4)	Dipeptidyl peptidase 4 UNIPROT P27487 DPP4 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank