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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M SAXAGLIPTIN (is an active metabolite)
| SAXAGLIPTIN |
ANTIDIABETIC | - | Cmax 149 NANOMOLAR (5 MILLIGRAM) VD 61 LITER (EQN) PPB 0 PERCENT Cl 13.8 LITER / HOUR HT 3.1 HOUR | DIPEPTIDYL PEPTIDASE-4 (DPP-4) | DIPEPTIDYL PEPTIDASE IV INHIBITOR CHEMBL284 DIPEPTIDYL PEPTIDASE IV P27487 DIPEPTIDYL PEPTIDASE 4 HOMO SAPIENS ENZYME PROTEASE SERINE SC S9B | ANSM (in French) | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SAXAGLIPTIN (has an active metabolite)
| SAXAGLIPTIN |
ANTIDIABETIC | ORAL | Cmax 76 NANOMOLAR (5 MILLIGRAM) VD 49.7 LITER (EQN) PPB 0 PERCENT Cl 13.8 LITER / HOUR HT 2.5 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | DIPEPTIDYL PEPTIDASE-4 (DPP-4) | DIPEPTIDYL PEPTIDASE IV INHIBITOR CHEMBL284 DIPEPTIDYL PEPTIDASE IV P27487 DIPEPTIDYL PEPTIDASE 4 HOMO SAPIENS ENZYME PROTEASE SERINE SC S9B | ANSM (in French) | |||
