PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
ANTIDIABETIC DIPEPTIDYL-PEPTIDASE IV INHIBITOR HYPOGLYCEMIC AGENTS TYPE 2 DIABETES MELLITUS METABOLISM METABOLITE OF SAXAGLIPTIN IS ONE-HALF AS POTENT AS SAXAGLIPTIN AS DPP4 INHIBITOR
-
Cmax 149 NANOMOLAR (5 MILLIGRAM)
VD 61 LITER (EQN)
PPB 0 PERCENT
Cl 13.8 LITER / HOUR
HT 3.1 HOUR
DIPEPTIDYL PEPTIDASE-4 (DPP-4)
DIPEPTIDYL PEPTIDASE IV INHIBITOR CHEMBL284 DIPEPTIDYL PEPTIDASE IV P27487 DIPEPTIDYL PEPTIDASE 4 HOMO SAPIENS ENZYME PROTEASE SERINE SC S9B
PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
ANTIDIABETIC DIPEPTIDYL-PEPTIDASE IV INHIBITOR HYPOGLYCEMIC AGENTS TYPE 2 DIABETES MELLITUS METABOLISM METABOLITE OF SAXAGLIPTIN IS ONE-HALF AS POTENT AS SAXAGLIPTIN AS DPP4 INHIBITOR
ORAL
Cmax 76 NANOMOLAR (5 MILLIGRAM)
VD 49.7 LITER (EQN)
PPB 0 PERCENT
Cl 13.8 LITER / HOUR
HT 2.5 HOUR
SOLUBILITY SPARINGLY SOLUBLE IN WATER
DIPEPTIDYL PEPTIDASE-4 (DPP-4)
DIPEPTIDYL PEPTIDASE IV INHIBITOR CHEMBL284 DIPEPTIDYL PEPTIDASE IV P27487 DIPEPTIDYL PEPTIDASE 4 HOMO SAPIENS ENZYME PROTEASE SERINE SC S9B