| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DESVENLAFAXINE (is an active metabolite)
| DESVENLAFAXINE | NERVOUS SYSTEM | ORAL | Cmax 1.1 MICROMOLAR Tmax 3 HOUR F 80 PERCENT VD 370 LITER (65 KILOGRAM) PPB 30 PERCENT Cl 26 LITER / HOUR (65 KILOGRAM) HT 11 HOUR SOLUBILITY SOLUBLE IN WATER PH DEPENDENT | SEROTONIN AND NOREPINEPHRINE REUPTAKE | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
