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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DEXMETHYLPHENIDATE (is an active metabolite)

DEXMETHYLPHENIDATE
METHYLPHENIDATE


ATC N06BA04

NERVOUS SYSTEM
CNS STIMULANT
ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)
DOPAMINE REUPTAKE INHIBITORS
NOREPINEPHRINE REUPTAKE INHIBITOR
NERVOUS SYSTEM

ORAL TRANSDERMAL

Cmax 73 NANOMOLAR (20 MILLIGRAM)

Tmax 6.8 HOUR

F 23.5 PERCENT

VD 169 LITER (65 KILOGRAM)

PPB 15 PERCENT

Cl 33 LITER / HOUR

HT 3.2 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
SODIUM-DEPENDENT DOPAMINE TRANSPORTER
SODIUM-DEPENDENT SEROTONIN TRANSPORTER

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3

more at DrugCentral

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Chemical Probes Portal

ChEMBL
BindingDB
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