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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DEXMETHYLPHENIDATE (is an active metabolite)
| DEXMETHYLPHENIDATE METHYLPHENIDATE | NERVOUS SYSTEM | ORAL TRANSDERMAL | Cmax 73 NANOMOLAR (20 MILLIGRAM) Tmax 6.8 HOUR F 23.5 PERCENT VD 169 LITER (65 KILOGRAM) PPB 15 PERCENT Cl 33 LITER / HOUR HT 3.2 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | SODIUM-DEPENDENT NORADRENALINE TRANSPORTER SODIUM-DEPENDENT DOPAMINE TRANSPORTER SODIUM-DEPENDENT SEROTONIN TRANSPORTER | Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SERDEXMETHYLPHENIDATE (has an active metabolite)
| SERDEXMETHYLPHENIDATE | NERVOUS SYSTEM | ORAL | Tmax 2 HOUR F 3 PERCENT VD 1904.5 LITER (65 KILOGRAM) PPB 56 PERCENT Cl 234 LITER / HOUR HT 5.7 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | SODIUM-DEPENDENT NORADRENALINE TRANSPORTER SODIUM-DEPENDENT DOPAMINE TRANSPORTER SODIUM-DEPENDENT SEROTONIN TRANSPORTER | Unknown more at DrugCentral | EMA | |||
