| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PYRAZINAMIDE (has an active metabolite)
| PYRAZINAMIDE |
ANTIINFECTIVES | ORAL | Cmax 227.8 MICROMOLAR F 96.8 PERCENT PPB 10 PERCENT Cl 3.82 LITER / HOUR HT 10 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | MYCOBACTERIAL PYRAZINAMIDASE (PNCA) PDB 5FPD (STRUCTURE OF HEAT SHOCK-RELATED 70KDA PROTEIN 2 WITH SMALL-MOLECULE LIGAND PYRAZINE-2-CARBOXAMIDE (AT513) IN AN ALTERNATE BINDING SITE.) LIGAND CODE = PZA (link to the list of PDB complexes) Download experimental 3D coordinates of PZA with added hydrogens | 3-oxoacyl-ACP synthase more at DrugCentral | EMA | |||
