| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PYRAZINAMIDE (has an active metabolite)
| PYRAZINAMIDE | ANTIINFECTIVES | ORAL | Cmax 227.8 MICROMOLAR F 96.8 PERCENT VD 55.1 LITER (EQN) PPB 10 PERCENT Cl 3.82 LITER / HOUR HT 10 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | MYCOBACTERIAL PYRAZINAMIDASE (PNCA) PDB 5FPD (STRUCTURE OF HEAT SHOCK-RELATED 70KDA PROTEIN 2 WITH SMALL-MOLECULE LIGAND PYRAZINE-2-CARBOXAMIDE (AT513) IN AN ALTERNATE BINDING SITE.) LIGAND CODE = PZA (link to the list of PDB complexes) Download experimental 3D coordinates of PZA with added hydrogens | FATTY ACID SYNTHASE INHIBITOR CHEMBL2011 FATTY ACID SYNTHASE P95029 3-OXOACYL-ACP SYNTHASE MYCOBACTERIUM TUBERCULOSIS ENZYME TRANSFERASE | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PYRAZINOIC ACID (is an active metabolite)
| PYRAZINOIC ACID | ANTIINFECTIVES | - | MYCOBACTERIAL PYRAZINAMIDASE (PNCA) XANTHINE OXYDASE PDB 4NNI (STRUCTURAL BASIS FOR TARGETING THE RIBOSOMAL PROTEIN S1 OF MYCOBACTERIUM TUBERCULOSIS BY PYRAZINAMIDE) LIGAND CODE = VGL (link to the list of PDB complexes) Download experimental 3D coordinates of VGL with added hydrogens | ENZYME P95029_MYCTU INHIBITOR P95029 | EMA | ||||
