e-Drug3D

349

OXAZEPAM

INN
OXAZEPAM

(is an active metabolite)

cas 604-75-1

CLASS

NERVOUS SYSTEM
ANXIOLYTIC
ANTI-ANXIETY AGENTS
GABA MODULATORS
HYPNOTICS AND SEDATIVES

ROUTE (list)

ORAL

ATC code

N05BA04

PK parameters

VD 38 LITER (65 KILOGRAM)
Cl 4.3 LITER / HOUR
PPB 96 PERCENT
t1/2 8.2 HOUR

Target

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR

DrugCentral

GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1

Download SDF file

7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

Formula:
C15H11ClN2O2

Calculated chemical properties:

MW 286.71
NB_atoms 20
XLogP 2.45
PSA 60.519
NB_HD 2
NB_HA 4
fsp3 0.07
Lipinski(0=no;1=yes) 1

FDA
NDA 070650 (pdf not found) INN (OXAZEPAM) ZAXOPAM (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071508 (pdf not found) INN (OXAZEPAM) OXAZEPAM (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071713 (pdf not found) INN (OXAZEPAM) OXAZEPAM (MYLAN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071714 (pdf not found) INN (OXAZEPAM) OXAZEPAM (MYLAN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071715 (pdf not found) INN (OXAZEPAM) OXAZEPAM (MYLAN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071955 (pdf not found) INN (OXAZEPAM) OXAZEPAM (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071956 (pdf not found) INN (OXAZEPAM) OXAZEPAM (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071957 (pdf not found) INN (OXAZEPAM) OXAZEPAM (AM THERAP) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 015539 (label) INN (OXAZEPAM) SERAX (ALPHARMA US PHARMS) APPROVAL= AP YEAR= 1965 DISCONTINUED
NDA 070683 (pdf not found) INN (OXAZEPAM) OXAZEPAM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070943 (pdf not found) INN (OXAZEPAM) OXAZEPAM (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070944 (pdf not found) INN (OXAZEPAM) OXAZEPAM (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070945 (pdf not found) INN (OXAZEPAM) OXAZEPAM (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071026 (pdf not found) INN (OXAZEPAM) OXAZEPAM (TP ANDA HOLDINGS) APPROVAL= AP YEAR= 1987
NDA 071494 (pdf not found) INN (OXAZEPAM) OXAZEPAM (WATSON LABS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071756 (pdf not found) INN (OXAZEPAM) OXAZEPAM (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1988
NDA 071813 (pdf not found) INN (OXAZEPAM) OXAZEPAM (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 071814 (pdf not found) INN (OXAZEPAM) OXAZEPAM (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 072251 (pdf not found) INN (OXAZEPAM) OXAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 072252 (pdf not found) INN (OXAZEPAM) OXAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 072253 (pdf not found) INN (OXAZEPAM) OXAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1988
NDA 070640 (pdf not found) INN (OXAZEPAM) ZAXOPAM (QUANTUM PHARMICS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 070641 (pdf not found) INN (OXAZEPAM) ZAXOPAM (QUANTUM PHARMICS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072952 (pdf not found) INN (OXAZEPAM) OXAZEPAM (WATSON LABS TEVA) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 072953 (pdf not found) INN (OXAZEPAM) OXAZEPAM (WATSON LABS) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 072954 (pdf not found) INN (OXAZEPAM) OXAZEPAM (WATSON LABS) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 218261 (pdf not found) INN (OXAZEPAM) OXAZEPAM (LEADING) APPROVAL= AP YEAR= 2025

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL

e-Drug3D

491

TEMAZEPAM

INN
TEMAZEPAM

(is an active metabolite) (has an active metabolite)

cas 846-50-4

CLASS

NERVOUS SYSTEM
HYPNOTICS AND SEDATIVES
BENZODIAZEPINES
GABA MODULATORS
ALLOSTERIC POSITIVE

ROUTE (list)

ORAL

ATC code

N05CD07

PK parameters

F 92 PERCENT
PPB 96 PERCENT
t1/2 8.8 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET GABA RECEPTOR

DrugCentral

GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1

Download SDF file

7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one

Formula:
C16H13ClN2O2

Calculated chemical properties:

MW 300.73
NB_atoms 21
XLogP 2.47
PSA 48.595
NB_HD 1
NB_HA 4
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
NDA 070383 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070384 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070489 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070490 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070547 (pdf not found) INN (TEMAZEPAM) TEMAZ (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070564 (pdf not found) INN (TEMAZEPAM) TEMAZ (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018163 (label) INN (TEMAZEPAM) RESTORIL (SPECGX LLC) APPROVAL= AP YEAR= 1981
NDA 070920 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071174 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071175 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071456 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (NOVEL LABS INC) APPROVAL= AP YEAR= 1987
NDA 071457 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (NOVEL LABS INC) APPROVAL= AP YEAR= 1987
NDA 071620 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1987
NDA 071638 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1987 OBSOLETE
NDA 071427 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (CHARTWELL RX) APPROVAL= AP YEAR= 1988
NDA 071428 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (CHARTWELL RX) APPROVAL= AP YEAR= 1988
NDA 071708 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071709 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071446 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (WATSON LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 071447 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (WATSON LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 078581 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 201781 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (PRINSTON INC) APPROVAL= AP YEAR= 2015
NDA 203482 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 211542 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (ALEMBIC) APPROVAL= AP YEAR= 2018
NDA 217875 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (ALKEM LABS LTD) APPROVAL= AP YEAR= 2023