e-Drug3D

491

cas 846-50-4

CLASS

NERVOUS SYSTEM
HYPNOTICS AND SEDATIVES
BENZODIAZEPINES
GABA MODULATORS
ALLOSTERIC POSITIVE

ROUTE (list)

ORAL

PK parameters

F 92 PERCENT
PPB 96 PERCENT
t1/2 8.8 HOUR

MW 300.73
NB_atoms 21
XLogP 2.47
PSA 48.595
NB_HD 1
NB_HA 4
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
NDA 070383 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070384 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070489 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070490 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070547 (pdf not found) INN (TEMAZEPAM) TEMAZ (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070564 (pdf not found) INN (TEMAZEPAM) TEMAZ (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018163 (label) INN (TEMAZEPAM) RESTORIL (SPECGX LLC) APPROVAL= AP YEAR= 1981
NDA 070920 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071174 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071175 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071456 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (NOVEL LABS INC) APPROVAL= AP YEAR= 1987
NDA 071457 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (NOVEL LABS INC) APPROVAL= AP YEAR= 1987
NDA 071620 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1987
NDA 071638 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1987 OBSOLETE
NDA 071427 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (CHARTWELL RX) APPROVAL= AP YEAR= 1988
NDA 071428 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (CHARTWELL RX) APPROVAL= AP YEAR= 1988
NDA 071708 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071709 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071446 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (WATSON LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 071447 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (WATSON LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 078581 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 201781 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (PRINSTON INC) APPROVAL= AP YEAR= 2015
NDA 203482 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 211542 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (ALEMBIC) APPROVAL= AP YEAR= 2018
NDA 217875 (pdf not found) INN (TEMAZEPAM) TEMAZEPAM (ALKEM LABS LTD) APPROVAL= AP YEAR= 2023

e-Drug3D

324

cas 439-14-5

CLASS

NERVOUS SYSTEM
ANXIOLYTIC
ANESTHETICS
ANTICONVULSANTS
ANTIEMETICS
GABA AGONIST
HYPNOTICS AND SEDATIVES
MUSCLE RELAXANTS, CENTRAL
BENZODIAZEPINE

ROUTE (list)

ORAL INJECTION RECTAL NASAL BUCCAL

PK parameters

F 90 PERCENT
Tmax 1.25 HOUR
VD 58.5 LITER (65 KILOGRAM)
Cl 1.5 LITER / HOUR
PPB 98 PERCENT
t1/2 46 HOUR

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR

PDB
2BXF (HUMAN SERUM ALBUMIN COMPLEXED WITH DIAZEPAM)

Ligand code = DZP (link to the list of PDB complexes)

Download experimental 3D coordinates of DZP with added hydrogens

MW 284.73
NB_atoms 20
XLogP 3.15
PSA 29.362
NB_HD 0
NB_HA 3
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
NDA 018179 (pdf not found) INN (DIAZEPAM) VALRELEASE (ROCHE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 019287 (pdf not found) INN (DIAZEPAM) DIZAC (PHARMACIA AND UPJOHN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070209 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070210 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070222 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070360 (pdf not found) INN (DIAZEPAM) DIAZEPAM (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070361 (pdf not found) INN (DIAZEPAM) DIAZEPAM (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070362 (pdf not found) INN (DIAZEPAM) DIAZEPAM (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070423 (pdf not found) INN (DIAZEPAM) Q-PAM (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070456 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070457 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070458 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070776 (pdf not found) INN (DIAZEPAM) DIAZEPAM (PIONEER PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070787 (pdf not found) INN (DIAZEPAM) DIAZEPAM (PIONEER PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070788 (pdf not found) INN (DIAZEPAM) DIAZEPAM (PIONEER PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070911 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070912 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070930 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070987 (pdf not found) INN (DIAZEPAM) DIAZEPAM (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070996 (pdf not found) INN (DIAZEPAM) DIAZEPAM (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071613 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071614 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072402 (pdf not found) INN (DIAZEPAM) DIAZEPAM (MARTEC USA LLC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072431 (pdf not found) INN (DIAZEPAM) Q-PAM (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072432 (pdf not found) INN (DIAZEPAM) Q-PAM (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072433 (pdf not found) INN (DIAZEPAM) Q-PAM (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 013263 (label) INN (DIAZEPAM) VALIUM (WAYLIS THERAP) APPROVAL= AP YEAR= 1963
NDA 016087 (pdf not found) INN (DIAZEPAM) VALIUM (ROCHE) APPROVAL= AP YEAR= 1966 DISCONTINUED
NDA 070152 (pdf not found) INN (DIAZEPAM) DIAZEPAM (BARR) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070153 (pdf not found) INN (DIAZEPAM) DIAZEPAM (TEVA PHARMS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070154 (pdf not found) INN (DIAZEPAM) DIAZEPAM (BARR) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070226 (pdf not found) INN (DIAZEPAM) DIAZEPAM (DAVA PHARMS INC) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070227 (pdf not found) INN (DIAZEPAM) DIAZEPAM (DAVA PHARMS INC) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070228 (pdf not found) INN (DIAZEPAM) DIAZEPAM (PH HEALTH) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070302 (pdf not found) INN (DIAZEPAM) DIAZEPAM (CHARTWELL RX) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070303 (pdf not found) INN (DIAZEPAM) DIAZEPAM (CHARTWELL RX) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070304 (pdf not found) INN (DIAZEPAM) DIAZEPAM (CHARTWELL RX) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070311 (label) INN (DIAZEPAM) DIAZEPAM (HIKMA) APPROVAL= AP YEAR= 1985
NDA 070312 (label) INN (DIAZEPAM) DIAZEPAM (HIKMA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070313 (label) INN (DIAZEPAM) DIAZEPAM (HIKMA) APPROVAL= AP YEAR= 1985
NDA 070325 (pdf not found) INN (DIAZEPAM) DIAZEPAM (MYLAN) APPROVAL= AP YEAR= 1985
NDA 070296 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070462 (pdf not found) INN (DIAZEPAM) DIAZEPAM (VIRTUS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070463 (pdf not found) INN (DIAZEPAM) DIAZEPAM (VIRTUS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070464 (pdf not found) INN (DIAZEPAM) DIAZEPAM (NUVO PHARM) APPROVAL= AP YEAR= 1986
NDA 070706 (pdf not found) INN (DIAZEPAM) DIAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070707 (pdf not found) INN (DIAZEPAM) DIAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070781 (pdf not found) INN (DIAZEPAM) DIAZEPAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070894 (pdf not found) INN (DIAZEPAM) DIAZEPAM (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070895 (pdf not found) INN (DIAZEPAM) DIAZEPAM (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070896 (pdf not found) INN (DIAZEPAM) DIAZEPAM (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070956 (pdf not found) INN (DIAZEPAM) DIAZEPAM (HALSEY) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071307 (pdf not found) INN (DIAZEPAM) DIAZEPAM (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1986
NDA 071321 (pdf not found) INN (DIAZEPAM) DIAZEPAM (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1986
NDA 071322 (pdf not found) INN (DIAZEPAM) DIAZEPAM (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1986
NDA 070424 (pdf not found) INN (DIAZEPAM) Q-PAM (QUANTUM PHARMICS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070425 (pdf not found) INN (DIAZEPAM) Q-PAM (QUANTUM PHARMICS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070903 (pdf not found) INN (DIAZEPAM) DIAZEPAM (FERNDALE LABS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070904 (pdf not found) INN (DIAZEPAM) DIAZEPAM (FERNDALE LABS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070905 (pdf not found) INN (DIAZEPAM) DIAZEPAM (FERNDALE LABS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070928 (pdf not found) INN (DIAZEPAM) DIAZEPAM (HIKMA) APPROVAL= AP YEAR= 1987
NDA 071134 (pdf not found) INN (DIAZEPAM) DIAZEPAM (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1987
NDA 071135 (pdf not found) INN (DIAZEPAM) DIAZEPAM (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1987
NDA 071136 (pdf not found) INN (DIAZEPAM) DIAZEPAM (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1987
NDA 071308 (label) INN (DIAZEPAM) DIAZEPAM (HIKMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071309 (label) INN (DIAZEPAM) DIAZEPAM (HIKMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071310 (label) INN (DIAZEPAM) DIAZEPAM (HIKMA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071415 (pdf not found) INN (DIAZEPAM) DIAZEPAM INTENSOL (HIKMA) APPROVAL= AP YEAR= 1987
NDA 071583 (pdf not found) INN (DIAZEPAM) DIAZEPAM (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 071584 (pdf not found) INN (DIAZEPAM) DIAZEPAM (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070662 (pdf not found) INN (DIAZEPAM) DIAZEPAM (ABRAXIS PHARM) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 072079 (pdf not found) INN (DIAZEPAM) DIAZEPAM (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 020124 (label) INN (DIAZEPAM) DIAZEPAM (US ARMY) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 070356 (pdf not found) INN (DIAZEPAM) DIAZEPAM (ROXANE) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 070357 (pdf not found) INN (DIAZEPAM) DIAZEPAM (ROXANE) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 070358 (pdf not found) INN (DIAZEPAM) DIAZEPAM (ROXANE) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 072370 (label) INN (DIAZEPAM) DIAZEPAM (WATSON LABS INC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072371 (pdf not found) INN (DIAZEPAM) DIAZEPAM (MARSAM PHARMS LLC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072397 (pdf not found) INN (DIAZEPAM) DIAZEPAM (WATSON LABS INC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020648 (label) INN (DIAZEPAM) DIASTAT (BAUSCH) APPROVAL= AP YEAR= 1997
NDA 076815 (pdf not found) INN (DIAZEPAM) DIAZEPAM (PARENTA PHARMS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077749 (pdf not found) INN (DIAZEPAM) DIAZEPAM (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 204433 (pdf not found) INN (DIAZEPAM) DIAZEPAM (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2014
NDA 206477 (pdf not found) INN (DIAZEPAM) DIAZEPAM (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2016
NDA 210363 (label) INN (DIAZEPAM) DIAZEPAM (REGCON HOLDINGS) APPROVAL= AP YEAR= 2019
NDA 211998 (label) INN (DIAZEPAM) DIAZEPAM (REGCON HOLDINGS) APPROVAL= AP YEAR= 2019
NDA 211635 (label) INN (DIAZEPAM) VALTOCO (NEURELIS INC) APPROVAL= AP YEAR= 2020
NDA 212641 (pdf not found) INN (DIAZEPAM) LIBERVANT (AQUESTIVE) APPROVAL= TA YEAR= 2022 NEWAPPLICATION
NDA 214745 (pdf not found) INN (DIAZEPAM) DIAZEPAM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2022
NDA 091076 (pdf not found) INN (DIAZEPAM) DIAZEPAM (NOVEL LABS INC) APPROVAL= AP YEAR= 2023
NDA 217843 (pdf not found) INN (DIAZEPAM) DIAZEPAM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023
NDA 218450 (pdf not found) INN (DIAZEPAM) DIAZEPAM (ALEMBIC) APPROVAL= AP YEAR= 2024
NDA 217178 (pdf not found) INN (DIAZEPAM) DIAZEPAM (LONG GROVE PHARMS) APPROVAL= AP YEAR= 2024
NDA 218422 (pdf not found) INN (DIAZEPAM) DIAZEPAM (DR REDDYS) APPROVAL= AP YEAR= 2024
NDA 218623 (pdf not found) INN (DIAZEPAM) LIBERVANT (AQUESTIVE) APPROVAL= TA YEAR= 2025
NDA 216422 (pdf not found) INN (DIAZEPAM) DIAZEPAM (GALENICUM HLTH) APPROVAL= AP YEAR= 2025
NDA 217468 (pdf not found) INN (DIAZEPAM) DIAZEPAM (NAVINTA LLC) APPROVAL= AP YEAR= 2025
NDA 219320 (pdf not found) INN (DIAZEPAM) DIAZEPAM (PADAGIS ISRAEL PHARMA LTD) APPROVAL= TA YEAR= 2025