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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ROFLUMILAST (has an active metabolite)
| ROFLUMILAST | RESPIRATORY | ORAL TOPICAL | F 80 PERCENT VD 188 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 9.6 LITER / HOUR HT 17 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PDE4 PHOSPHODIESTERASE 4 PDB 1XMU (CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH ROFLUMILAST) LIGAND CODE = ROF (link to the list of PDB complexes) Download experimental 3D coordinates of ROF with added hydrogens | PHOSPHODIESTERASE 4 INHIBITOR CHEMBL2093863 PHOSPHODIESTERASE 4 P27815 CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A HOMO SAPIENS ENZYME PHOSPHODIESTERASE PDE_4 PDE_4A | EMA | |||
