M ROFLUMILAST (is an active metabolite) | ROFLUMILAST | ATC R03DX07
RESPIRATORY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PHOSPHODIESTERASE PDE4 INHIBITORS ROFLUMILAST IS THREE TIMES MORE POTENT THAN ROFLUMILAST N-OXIDE AT INHIBITION OF THE PDE4 ENZYME IN VITRO THE PLASMA AUC OF ROFLUMILAST N-OXIDE ON AVERAGE IS ABOUT 10-FOLD GREATER THAN THE PLASMA AUC OF ROFLUMILAST | - | PPB 97 PERCENT HT 30 HOUR | PDE4 PHOSPHODIESTERASE 4 | PHOSPHODIESTERASE 4 INHIBITOR CHEMBL2093863 PHOSPHODIESTERASE 4 P27815 CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A HOMO SAPIENS ENZYME PHOSPHODIESTERASE PDE_4 PDE_4A | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |
ROFLUMILAST (has an active metabolite) | ROFLUMILAST | ATC R03DX07
RESPIRATORY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PHOSPHODIESTERASE PDE4 INHIBITORS ROFLUMILAST IS THREE TIMES MORE POTENT THAN ROFLUMILAST N-OXIDE AT INHIBITION OF THE PDE4 ENZYME IN VITRO THE PLASMA AUC OF ROFLUMILAST N-OXIDE ON AVERAGE IS ABOUT 10-FOLD GREATER THAN THE PLASMA AUC OF ROFLUMILAST | ORAL TOPICAL | F 80 PERCENT VD 188 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 9.6 LITER / HOUR HT 17 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PDE4 PHOSPHODIESTERASE 4 PDB 1XMU (CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH ROFLUMILAST) LIGAND CODE = ROF (link to the list of PDB complexes) Download experimental 3D coordinates of ROF with added hydrogens | PHOSPHODIESTERASE 4 INHIBITOR CHEMBL2093863 PHOSPHODIESTERASE 4 P27815 CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A HOMO SAPIENS ENZYME PHOSPHODIESTERASE PDE_4 PDE_4A | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |