| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CHLORAMPHENICOL DISCONTINUED (is an active metabolite)
| CHLORAMPHENICOL |
ANTIINFECTIVES | OPHTHALMIC INJECTION TOPICAL OTIC ORAL | VD 61 LITER (65 KILOGRAM) PPB 66 PERCENT Cl 9.3 LITER / HOUR (65 KILOGRAM) HT 4.6 HOUR | 50S RIBOSOMAL PROTEIN PDB 4V7W (STRUCTURE OF THE THERMUS THERMOPHILUS RIBOSOME COMPLEXED WITH CHLORAMPHENICOL) LIGAND CODE = CLM (link to the list of PDB complexes) Download experimental 3D coordinates of CLM with added hydrogens | Unknown more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CHLORAMPHENICOL PALMITATE DISCONTINUED (has an active metabolite)
| CHLORAMPHENICOL PALMITATE |
DERMATOLOGICAL | ORAL | 50S RIBOSOMAL PROTEIN | BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL2363135 BACTERIAL 70S RIBOSOME 23S RIBOSOMAL RNA BACTERIA more at DrugCentral | EMA | ||||
