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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CALCITRIOL (is an active metabolite)
| CALCITRIOL | METABOLISM | ORAL INJECTION TOPICAL | Cmax 0.14 NANOMOLAR Tmax 4.5 HOUR PPB 99.9 PERCENT HT 6.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | VITAMIN D3 RECEPTOR PDB 1DB1 (CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D) LIGAND CODE = VDX (link to the list of PDB complexes) Download experimental 3D coordinates of VDX with added hydrogens | VITAMIN D RECEPTOR AGONIST CHEMBL1977 VITAMIN D RECEPTOR P11473 VITAMIN D3 RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR1 NR1I NR1I1 | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CHOLECALCIFEROL (has an active metabolite)
| CHOLECALCIFEROL |
METABOLISM | INTRAVENOUS ORAL | Cmax 10.4 NANOMOLAR Tmax 10.6 HOUR HT 14 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | VITAMIN D3-25-HYDROXYLASE (25-OHASE) | VITAMIN D RECEPTOR AGONIST CHEMBL1977 VITAMIN D RECEPTOR P11473 VITAMIN D3 RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR1 NR1I NR1I1 | EMA | |||
