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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ETHINYL ESTRADIOL (is an active metabolite)
| ETHINYL ESTRADIOL | GENITO | ORAL TRANSDERMAL VAGINAL | Cmax 418.9 NANOMOLAR Tmax 1.27 HOUR VD 279.5 LITER (65 KILOGRAM) PPB 97 PERCENT Cl 27.3 LITER / HOUR (65 KILOGRAM) HT 9.7 HOUR | ESTROGEN RECEPTOR PDB 4X1G (CRYSTAL STRUCTURE OF THE HPXR-LBD IN COMPLEX WITH THE SYNTHETIC ESTROGEN 17ALPHA-ETHINYLESTRADIOL AND THE PESTICIDE TRANS-NONACHLOR) LIGAND CODE = 3WF (link to the list of PDB complexes) Download experimental 3D coordinates of 3WF with added hydrogens | ESTROGEN RECEPTOR ALPHA AGONIST CHEMBL206 ESTROGEN RECEPTOR ALPHA P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1 | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| QUINESTROL DISCONTINUED (has an active metabolite)
| QUINESTROL | GENITO | ORAL | ESTROGEN RECEPTOR | ESTROGEN RECEPTOR AGONIST CHEMBL2093866 ESTROGEN RECEPTOR P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1 | EMA | ||||
