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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ELAFIBRANOR (has an active metabolite)
| ELAFIBRANOR | METABOLISM | ORAL | Cmax 2.08 MICROMOLAR Tmax 1.25 HOUR VD 4731 LITER PPB 99.7 PERCENT Cl 50.0 LITER / HOUR HT 70.2 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE AT PH 7.5 | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) PDB 8HUQ (X-RAY STRUCTURE OF HUMAN PPAR ALPHA LIGAND BINDING DOMAIN-ELAFIBRANOR-SRC1 COACTIVATOR PEPTIDE CO-CRYSTALS OBTAINED BY SOAKING) LIGAND CODE = MUO (link to the list of PDB complexes) Download experimental 3D coordinates of MUO with added hydrogens | - more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M ELAFIBRANOR (is an active metabolite)
| ELAFIBRANOR | METABOLISM | - | Cmax 5.35 MICROMOLAR PPB 99.7 PERCENT HT 15.4 HOUR | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) | - more at DrugCentral | EMA | |||
